James McMahon

Learn more about the people at Monash Infectious Diseases.

James McMahon

MBBS (U Melb) FRACP MPH (Tufts, USA) PhD (Monash)

Infectious Diseases Physician

Infectious Diseases Physician, Alfred Hospital
Adjunct Assistant Professor of Medicine, Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA

Professional Roles
2011               Consultant, VMVN study, Bach Mai Hospital, Hanoi, Vietnam
2009-             Consultant, WHO HIV Drug Resistance Prevention & Treatment Strategy
2008-2013     Study Director, ART adherence in the public health model of HIV care,
Christian Medical College, Vellore,  Tamil Nadu, India
2007-2010      Clinical & Research Fellow, Dept Infectious Diseases & Geographic Medicine, Tufts University School of Medicine, Boston, MA, USA

2010 – 2013    NHMRC Postgraduate Scholarship, Australia
2012               Best Poster, ASID Conference 2012, Perth, WA, Australia
2011               Best poster Track D: HIV in populations, ASHM Conference 2011
2011               ASHM Domestic Scholarship, ASHM Conference, Canberra, Australia
2011               Grand finalist, Quantia MD National Case Challenge, USA
2009               Tufts MPH Global Health International Travel Scholarship, USA

Book chapters

Antiretroviral therapy
McMahon JH. Vujovic O.
HIV Management in Australasia. A Guide for Clinical Care
Australasian Society for HIV Medicine, 2017

Monitoring of antiretroviral efficacy without access to routine HIV viral load testing.
Elliott J, Van Griensven J, McMahon J, Lynen L.
In: Gupta S, Kumar B. eds.
Sexually Transmitted Infections 2nd ed. New Delhi, India: Elsevier, 2012

Journal Articles

The effect of antiretroviral intensification with dolutegravir on residual virus replication in HIV-infected individuals: a randomised, placebo-controlled, double-blind trial.
Rasmussen TA, McMahon JH, Chang JJ, Audsley J, Rhodes A, Tennakoon S, Dantanarayana A, Spelman T, Schmidt T, Kent SJ, Morcilla V, Palmer S, Elliott JH, Lewin SR.
Lancet HIV. 2018 Apr 6. pii: S2352-3018(18)30040-7. doi: 10.1016/S2352-3018(18)30040-7. [Epub ahead of print]
PMID: 29643011

Concomitant medication polypharmacy, interactions and imperfect adherence are common in Australian adults on suppressive ART.
Siefried KJ, Mao L, Cysique LA, Rule J, Giles ML, Smith DE, Mcmahon J, Read TR, Ooi C, Tee BK, Bloch M, de Wit J, Carr A; PAART study investigators.
AIDS. 2017 Nov 10. doi: 10.1097/QAD.0000000000001685.

Time from HIV diagnosis to commencement of antiretroviral therapy as an indicator to supplement the HIV cascade: Dramatic fall from 2011 to 2015.
Medland NA, Chow EPF, McMahon JH, Elliott JH, Hoy JF, Fairley CK.
PLoS One. 2017 May 16;12(5):e0177634. doi: 10.1371/journal.pone.0177634. eCollection 2017.
PMID: 28520807

Impact of alemtuzumab on HIV persistence in an HIV-infected individual on antiretroviral therapy with Sezary syndrome.
Rasmussen TA, McMahon J, Chang JJ, Symons J, Roche M, Dantanarayana A, Okoye A, Hiener B, Palmer S, Lee WS, Kent S, Van Der Weyden C, Prince HM, Cameron PU, Lewin SR.
AIDS. 2017 May 16. doi: 10.1097/QAD.0000000000001540. [Epub ahead of print]
PMID: 28514279

Post-treatment control in an adult with perinatally acquired HIV following cessation of antiretroviral therapy.
McMahon JH, Chang J, Tennakoon S, Dantanarayana A, Solomon A, Cherry C, Doherty R, Cameron P, Lewin SR.
AIDS. 2017 Jun 1;31(9):1344-1346. doi: 10.1097/QAD.0000000000001472. No abstract available.
PMID: 28492397

Less frequent CD4 monitoring in virologically suppressed HIV.
McMahon J, Crowe SM.
Lancet HIV. 2017 Jun;4(6):e233-e234. doi: 10.1016/S2352-3018(17)30070-X. Epub 2017 Apr 11. No abstract available.
PMID: 28411090

No adverse safety or virological changes two years following vorinostat in HIV-infected individuals on antiretroviral therapy.
Mota TM, Rasmussen TA, Rhodes A, Tennakoon S, Dantanarayana A, Wightman F, Hagenauer M, Roney J, Spelman T, Purcell DF, McMahon J, Hoy JF, Prince HM, Elliott JH, Lewin SR.
AIDS. 2017 Mar 15. doi: 10.1097/QAD.0000000000001442. [Epub ahead of print]
PMID: 28301423

Integrase resistant HIV in an antiretroviral naive patient in Australia.
Rafiei N, Woolley I, Korman TM, Chibo D, Gooey M, McMahon JH.
AIDS 2017 Feb 20;31(4):598-600. doi: 10.1097/QAD.0000000000001377. No abstract available.
PMID: 28118237

A longitudinal cohort study of HIV ‘treatment as prevention’ in gay, bisexual and other men who have sex with men: the Treatment with Antiretrovirals and their Impact on Positive And Negative men (TAIPAN) study protocol.
Callander D, Stoové M, Carr A, Hoy JF, Petoumenos K, Hellard M, Elliot J, Templeton DJ, Liaw S, Wilson DP, Grulich A, Cooper DA, Pedrana A, Donovan B, McMahon J, Prestage G, Holt M, Fairley CK, McKellar-Stewart N, Ruth S, Asselin J, Keen P, Cooper C, Allan B, Kaldor JM, Guy R.
BMC Infect Dis. 2016 Dec 12;16(1):752.
PMID: 27955627

Broad activation of latent HIV-1 in vivo.
Barton K, Hiener B, Winckelmann A, Rasmussen TA, Shao W, Byth K, Lanfear R, Solomon A, McMahon J, Harrington S, Buzon M, Lichterfeld M, Denton PW, Olesen R, Østergaard L, Tolstrup M, Lewin SR, Søgaard OS, Palmer S.
Nat Commun. 2016 Sep 8;7:12731. doi: 10.1038/ncomms12731.
PMID: 27605062

Risk factors for unstructured treatment interruptions and association with survival in low to middle income countries.
McMahon JH, Spelman T, Ford N, Greig J, Mesic A, Ssonko C, Casas EC, O’Brien DP.
AIDS Res Ther. 2016 Jul 11;13:25. doi: 10.1186/s12981-016-0109-8. eCollection 2016.
PMID: 27408611

Risk factors for mortality during antiretroviral therapy in older populations in resource-limited settings.
O’Brien D, Spelman T, Greig J, McMahon J, Ssonko C, Casas E, Mesic A, Du Cros P, Ford N.
J Int AIDS Soc. 2016 Jan 14;19(1):20665. doi: 10.7448/IAS.19.1.20665. eCollection 2016.
PMID: 26782169

The HIV care cascade: a systematic review of data sources, methodology and comparability.
Medland NA, McMahon JH, Chow EP, Elliott JH, Hoy JF, Fairley CK.
J Int AIDS Soc. 2015 Nov 30;18(1):20634. doi: 10.7448/IAS.18.1.20634. eCollection 2015.
PMID: 26626715

Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study.
Elliott JH, McMahon JH, Chang CC, Lee SA, Hartogensis W, Bumpus N, Savic R, Roney J, Hoh R, Solomon A, Piatak M, Gorelick RJ, Lifson J, Bacchetti P, Deeks SG, Lewin SR.
Lancet HIV. 2015 Dec;2(12):e520-9. doi: 10.1016/S2352-3018(15)00226-X. Epub 2015 Nov 17.
PMID: 26614966

90-90-90: how do we get there?
McMahon JH, Medland N.
Lancet HIV. 2014 Oct;1(1):e10-1. doi: 10.1016/S2352-3018(14)70017-7. Epub 2014 Sep 29. No abstract available.
PMID: 26423810

Long-term Virological Outcomes of First-Line Antiretroviral Therapy for HIV-1 in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.
Boender TS, Sigaloff KC, McMahon JH, Kiertiburanakul S, Jordan MR, Barcarolo J, Ford N, Rinke de Wit TF, Bertagnolio S.
Clin Infect Dis. 2015 Nov 1;61(9):1453-61. doi: 10.1093/cid/civ556. Epub 2015 Jul 8.
PMID: 26157050

Clinic Network Collaboration and Patient Tracing to Maximize Retention in HIV Care.
McMahon JH, Moore R, Eu B, Tee BK, Chen M, El-Hayek C, Street A, Woolley I, Buggie A, Collins D, Medland N, Hoy J; Victorian Initiative for Patient Engagement and Retention (VIPER) study group.
PLoS One. 2015 May 26;10(5):e0127726. doi: 10.1371/journal.pone.0127726. eCollection 2015.
PMID: 26011034

Experiences and expectations of participants completing an HIV cure focused clinical trial.
McMahon JH, Elliott JH, Roney J, Hagenauer M, Lewin SR.
AIDS. 2015 Jan 14;29(2):248-50. doi: 10.1097/QAD.0000000000000534. No abstract available.
PMID: 25532611 [PubMed – in process]

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy.
Elliott JH, Wightman F, Solomon A, Ghneim K, Ahlers J, Cameron MJ, Smith MZ, Spelman T, McMahon J, Velayudham P, Brown G, Roney J, Watson J, Prince MH, Hoy JF, Chomont N, Fromentin R, Procopio FA, Zeidan J, Palmer S, Odevall L, Johnstone RW, Martin BP, Sinclair E, Deeks SG, Hazuda DJ, Cameron PU, Sékaly RP, Lewin SR.
PLoS Pathog. 2014 Nov 13;10(10):e1004473. doi: 10.1371/journal.ppat.1004473. eCollection 2014 Oct.
PMID: 25393648 [PubMed – in process]

Targets for intervention to improve virological outcomes for patients receiving free antiretroviral therapy in Tamil Nadu, India.
McMahon JH, Manoharan A, Wanke C, Mammen S, Jose H, Malini T, Kadavanu T, Jordan MR, Elliott JH, Lewin SR, Mathai D.
AIDS Care. 2014;26(5):559-66. doi: 10.1080/09540121.2013.845282. Epub 2013 Oct 15.
PMID: 24125035 [PubMed – in process]

Viral suppression after 12 months of antiretroviral therapy in low- and middle-income countries: a systematic review.
McMahon JH, Elliott JH, Bertagnolio S, Kubiak R, Jordan MR.
Bull World Health Organ. 2013 May 1;91(5):377-385E. doi: 10.2471/BLT.12.112946. Epub 2013 Feb 21.
PMID: 23678201 [PubMed – in process]

Pharmacy and Self-Report Adherence Measures to Predict Virological Outcomes for Patients on Free Antiretroviral Therapy in Tamil Nadu, India.
McMahon JH, Manoharan A, Wanke CA, Mammen S, Jose H, Malini T, Kadavanu T, Jordan MR, Elliott JH, Lewin SR, Mathai D.
AIDS Behav. 2013 Jul;17(6):2253-9. doi: 10.1007/s10461-013-0436-x.
PMID: 23435750 [PubMed – indexed for MEDLINE]

Effects of physical tracing on estimates of loss to follow-up, mortality and retention in low and middle income country antiretroviral therapy programs: a systematic review.
McMahon JH, Elliott JH, Hong SY, Bertagnolio S, Jordan MR.
PLoS One. 2013;8(2):e56047. doi: 10.1371/journal.pone.0056047. Epub 2013 Feb 12.
PMID: 23424643 [PubMed – in process]

HIV drug resistance early warning indicators in cohorts of individuals starting antiretroviral therapy between 2004 and 2009: World Health Organization global report from 50 countries.
Bennett DE, Jordan MR, Bertagnolio S, Hong SY, Ravasi G, McMahon JH, Saadani A, Kelley KF.
Clin Infect Dis. 2012 May;54 Suppl 4:S280-9. doi: 10.1093/cid/cis207.
PMID: 22544188 [PubMed – indexed for MEDLINE]

Update on World Health Organization HIV drug resistance prevention and assessment strategy: 2004-2011.
Jordan MR, Bennett DE, Wainberg MA, Havlir D, Hammer S, Yang C, Morris L, Peeters M, Wensing AM, Parkin N, Nachega JB, Phillips A, De Luca A, Geng E, Calmy A, Raizes E, Sandstrom P, Archibald CP, Perriëns J, McClure CM, Hong SY, McMahon JH, Dedes N, Sutherland D, Bertagnolio S.
Clin Infect Dis. 2012 May;54 Suppl 4:S245-9. doi: 10.1093/cid/cis206.
PMID: 22544182 [PubMed – indexed for MEDLINE]

Poverty, hunger, education, and residential status impact survival in HIV.
McMahon J, Wanke C, Terrin N, Skinner S, Knox T.
AIDS Behav. 2011 Oct;15(7):1503-11. doi: 10.1007/s10461-010-9759-z.
PMID: 20632079 [PubMed – indexed for MEDLINE] Free PMC Article

Repeated assessments of food security predict CD4 change in the setting of antiretroviral therapy.
McMahon JH, Wanke CA, Elliott JH, Skinner S, Tang AM.
J Acquir Immune Defic Syndr. 2011 Sep 1;58(1):60-3. doi: 10.1097/QAI.0b013e318227f8dd.
PMID: 21694604 [PubMed – indexed for MEDLINE]

Pharmacy adherence measures to assess adherence to antiretroviral therapy: review of the literature and implications for treatment monitoring.
McMahon JH, Jordan MR, Kelley K, Bertagnolio S, Hong SY, Wanke CA, Lewin SR, Elliott JH.
Clin Infect Dis. 2011 Feb 15;52(4):493-506. doi: 10.1093/cid/ciq167. Epub 2011 Jan 18.
PMID: 21245156 [PubMed – indexed for MEDLINE]

Histologic, immunohistochemical, microbiological, molecular biological and ultrastructural characterization of pulmonary tularemia.
Navarro P, Garcia-Moliner ML, McMahon JH, Telford SR 3rd, Zoukhri D, Alroy J.
Pathol Res Pract. 2011 Jan 15;207(1):63-6. doi: 10.1016/j.prp.2010.07.002. Epub 2010 Aug 14.
PMID: 20709464 [PubMed – indexed for MEDLINE]

Torsades de pointes in a patient receiving fluconazole for cerebral cryptococcosis.
McMahon JH, Grayson ML.
Am J Health Syst Pharm. 2008 Apr 1;65(7):619-23. doi: 10.2146/ajhp070203.
PMID: 18359968 [PubMed – indexed for MEDLINE]

Is hospital-in-the-home (HITH) treatment of bacterial endocarditis safe and effective?
McMahon JH, O’keeffe JM; Victorian Hith Outcomes Study Group, Grayson ML.
Scand J Infect Dis. 2008;40(1):40-3. Epub 2007 Aug 3.
PMID: 17852904
[PubMed – indexed for MEDLINE]

Yoghurt consumption and damaged colonic mucosa: a case of Lactococcus lactis liver abscess in an immunocompetent patient.
Denholm J, Horne K, McMahon J, Grayson ML, Johnson P.
Scand J Infect Dis. 2006;38(8):739-41.
PMID: 16857633 [PubMed – indexed for MEDLINE