Clinical Trials – Advancing Autoimmune Research

Monash Rheumatology, in collaboration with Monash Haematology, continues to lead Australia in pioneering clinical research for severe autoimmune diseases.

YTB323 Study – A Milestone in Autoimmune Therapy

We are proud to have successfully treated the first SLE patient in Australia with YTB323 (Novartis), a cutting-edge CAR-T cell therapy. Although this study is now closed to recruitment, it represents a major advancement in the treatment of autoimmune conditions.

Monash Nephrology are currently recruiting Lupus Nephritis patients for the Phase II YTB study.

Now recruiting: Allogeneic CAR-T Cell Therapy Study

We are currently recruiting for a new allogeneic CAR-T cell therapy study targeting:

• Systemic Lupus Erythematosus (SLE)
• Lupus Nephritis (LN)
• ANCA-Associated Vasculitis (AAV)

This study uses a novel CAR-T product developed by Sana Biotechnology Inc., aiming to deliver transformative outcomes for patients with severe, treatment-resistant autoimmune diseases.

Closing soon: Phase III – IL17 v IL23 for active PsA

Only a few spots left globally so please get in touch.

Now recruiting: Phase III Sjögren’s Disease Study

We are also recruiting for a Phase III clinical trial investigating the efficacy and safety of Efgartigimod, a therapy designed to reduce disease-causing IgG antibodies.

Patients diagnosed with Sjögren’s Disease who meet eligibility criteria are encouraged to participate.

For referrals or more information, contact:
Professor Alberta Hoi – RheumatologyClinicalTrials@monashhealth.org

Coming in 2026: Allogeneic CAR-T Study

Launching in 2026, a second allogeneic CAR-T study will focus on:

• SLE
• Systemic Sclerosis (Scleroderma)
• Rheumatoid Arthritis
• Idiopathic Inflammatory Myositis

These studies are conducted in close partnership with Monash Haematology, reinforcing our commitment to collaborative, multidisciplinary care and research excellence.

For referrals or more information, contact:
Professor Eric Morand – RheumatologyClinicalTrials@monashhealth.org

Current Rheumatology clinical trials

Please click the link below to view all current clinical trials – updated quarterly with new trials.