Research Studies


Clinical Trials



Managing HBV in pregnancy. Prevention, prophylaxis, treatment and follow-up: position paper produced by Australian, UK and New Zealand key opinion leaders.
Visvanathan K, Dusheiko G, Giles M, Wong ML, Phung N, Walker S, Le S, Lim SG, Gane E, Ngu M, Hardikar W, Cowie B, Bowden S, Strasser S, Levy M, Sasaduesz J.
Gut. 2016 Feb;65(2):340-50. doi: 10.1136/gutjnl-2015-310317. Epub 2015 Oct 15. Review.
PMID: 26475631

Deshpande S, Ko T, Roberts E, Lau JS, Horne K, Williams J, Kiss C, Ratnam D,Woolley I.
J Acquir Immune Defic Syndr. 2015 Oct 20. [Epub ahead of print] No abstract available. PMID: 26488453

Clinical and virological predictors of hepatic flares in pregnant women with chronic hepatitis B.
Giles M, Visvanathan K, Lewin S, Bowden S, Locarnini S, Spelman T, Sasadeusz J.
Gut. 2015 Nov;64(11):1810-5. doi: 10.1136/gutjnl-2014-308211. Epub 2014 Nov 27.
PMID: 25431458

Prevention of mother-to-child transmission of hepatitis B virus (HBV) during pregnancy and the puerperium: Current standards of care.
Giles ML, Grace R, Tai A, Michalak K, Walker SP.
Aust N Z J Obstet Gynaecol. 2013 Mar 4. doi: 10.1111/ajo.12061. [Epub ahead of print]
PMID:23452292 [PubMed – as supplied by publisher]

IL28B genotype is not useful for predicting treatment outcome in Asian chronic hepatitis B patients treated with pegylated interferon-α
Holmes JA, Nguyen T, Ratnam D, Heerasing NM, Tehan JV, Bonanzinga S, Dev A, Bell S, Pianko S, Chen R, Visvanathan K, Hammond R, Iser D, Rusli F, Sievert W, Desmond PV, Bowden DS, Thompson AJ.
J Gastroenterol Hepatol. 2013 Jan 9. doi: 10.1111/jgh.12110. [Epub ahead of print]
PMID:23301835 [PubMed – as supplied by publisher]

Clinical Implications of the Innate and Adaptive Immune Response to HBV and HCV.
Le ST, Visvanathan K.
Curr Hepatitis Rep 2012;11:243-249.

Natural killer cells display impaired responses to toll like receptor 9 that support viral persistence in chronic hepatitis B.
Ratnam DT, Sievert W, Visvanathan K.
Cell Immunol. 2012 Sep;279(1):109-15. doi:10.1016/j.cellimm.2012.09.005. Epub 2012 Oct 16.
PMID:23123793 [PubMed – in process]

Chronic Hepatitis B Infection and Pregnancy.
Giles ML, Visvanathan K, Lewin SR, Sasadeusz J.
Obstet Gynecol Surv. 2012 Jan;67(1):37-44.
PMID: 22278077 [PubMed – as supplied by publisher]

Antiviral therapy for hepatitis B infection during pregnancy and breastfeeding.
Giles M, Visvanathan K, Sasadeusz J.
Antivir Ther. 2011;16(5):621-8.
PMID: 21817183 [PubMed – in process]

Polymorphisms of Toll-like receptors and their pathways in viral hepatitis.
Sawhney R, Visvanathan K.
Antivir Ther. 2011;16(4):443-58.
PMID: 21685532 [PubMed – in process]

The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway.
Lang T, Lo C, Skinner N, Locarnini S, Visvanathan K, Mansell A.
J Hepatol. 2011 Feb 17. [Epub ahead of print]
PMID: 21334391 [PubMed – as supplied by publisher]

Acute allograft rejection in human liver transplant recipients is associated with signaling through toll-like receptor 4.
Testro AG, Visvanathan K, Skinner N, Markovska V, Crowley P, Angus PW, Gow PJ.
J Gastroenterol Hepatol. 2011 Jan;26(1):155-63. doi: 10.1111/j.1440-1746.2010.06324.x.
PMID: 21175809 [PubMed – in process]

Serum hepatitis B surface antigen and hepatitis B e antigen titers: disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers.
Thompson AJ, Nguyen T, Iser D, Ayres A, Jackson K, Littlejohn M, Slavin J, Bowden S, Gane EJ, Abbott W, Lau GK, Lewin SR, Visvanathan K, Desmond PV, Locarnini SA.
Hepatology. 2010 Jun;51(6):1933-44.
PMID: 20512987 [PubMed – indexed for MEDLINE]

Effects of antibiotics on expression and function of Toll-like receptors 2 and 4 on mononuclear cells in patients with advanced cirrhosis.
Testro AG, Gow PJ, Angus PW, Wongseelashote S, Skinner N, Markovska V, Visvanathan K.
J Hepatol. 2010 Feb;52(2):199-205. Epub 2009 Dec 16.
PMID: 20006396 [PubMed – indexed for MEDLINE]

Stimulation of the interleukin-1 receptor and Toll-like receptor 2 inhibits hepatitis B virus replication in hepatoma cell lines in vitro.
Thompson AJ, Colledge D, Rodgers S, Wilson R, Revill P, Desmond P, Mansell A, Visvanathan K, Locarnini S.
Antivir Ther. 2009;14(6):797-808.
PMID: 19812442 [PubMed – indexed for MEDLINE]

A novel role for human leukocyte antigen-DP in chronic hepatitis B infection: a genomewide association study.
Howell JA, Visvanathan K.
Hepatology. 2009 Aug;50(2):647-9. No abstract available.
PMID: 19642163 [PubMed]

Toll-like receptors and their role in gastrointestinal disease.
Testro AG, Visvanathan K.
J Gastroenterol Hepatol. 2009 Jun;24(6):943-54. Review.
PMID: 19638078 [PubMed – in process]

Immunopathogenesis of hepatic flare in HIV/hepatitis B virus (HBV)-coinfected individuals after the initiation of HBV-active antiretroviral therapy.
Crane M, Oliver B, Matthews G, Avihingsanon A, Ubolyam S, Markovska V, Chang JJ, Dore GJ, Price P, Visvanathan K, French M, Ruxrungtham K, Lewin SR.
J Infect Dis. 2009 Apr 1;199(7):974-81.
PMID: 19231993 [PubMed – indexed for MEDLINE]

Characterization of the innate immune signalling pathways in hepatocyte cell lines.
Preiss S, Thompson A, Chen X, Rodgers S, Markovska V, Desmond P, Visvanathan K, Li K, Locarnini S, Revill P.
J Viral Hepat. 2008 Dec;15(12):888-900. Epub 2008 Jul 28.
PMID: 18673429 [PubMed – indexed for MEDLINE]

New concepts in the immunopathogenesis of chronic hepatitis B: the importance of the innate immune response.
Ratnam D, Visvanathan K.
Hepatol Int. 2008 May;2(Supplement 1):12-8. Epub 2008 Feb 27.
PMID: 19669294 [PubMed – in process]Free PMC ArticleFree text

Isolated core antibody hepatitis B in sub-Saharan African immigrants.
Gibney KB, Torresi J, Lemoh C, Biggs BA.
J Med Virol. 2008 Sep;80(9):1565-9.
PMID: 18649341 [PubMed – indexed for MEDLINE]

The phenotype of hepatitis B virus-specific T cells differ in the liver and blood in chronic hepatitis B virus infection.
Chang JJ, Thompson AJ, Visvanathan K, Kent SJ, Cameron PU, Wightman F, Desmond P, Locarnini SA, Lewin SR.
Hepatology. 2007 Nov;46(5):1332-40.
PMID: 17924445 [PubMed – indexed for MEDLINE]

The natural history and the staging of chronic hepatitis B: time for reevaluation of the virus-host relationship based on molecular virology and immunopathogenesis considerations?
Thompson A, Locarnini S, Visvanathan K.
Gastroenterology. 2007 Sep;133(3):1031-5. No abstract available.
PMID: 17854605 [PubMed – indexed for MEDLINE]

Synbiotic-associated improvement in liver function in cirrhotic patients: Relation to changes in circulating cytokine messenger RNA and protein levels.

Riordan SM, Skinner NA, McIver CJ, Liu Q, Bengmark S, Bihari D, Visvanathan K.
Microb Ecol Health Dis. 2007;19(1):7-16.

Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein.
Visvanathan K, Skinner NA, Thompson AJ, Riordan SM, Sozzi V, Edwards R, Rodgers S, Kurtovic J, Chang J, Lewin S, Desmond P, Locarnini S.
Hepatology. 2007 Jan;45(1):102-10.
PMID: 17187404 [PubMed – indexed for MEDLINE]

Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B.
Riordan SM, Skinner N, Kurtovic J, Locarnini S, Visvanathan K.
Clin Vaccine Immunol. 2006 Aug;13(8):972-4.
PMID: 16894001 [PubMed – indexed for MEDLINE]Free PMC ArticleFree text

Immunopathogenesis: role of innate and adaptive immune responses.
Visvanathan K, Lewin SR.
Semin Liver Dis. 2006 May;26(2):104-15. Review.
PMID: 16673289 [PubMed – indexed for MEDLINE]

Regulation of Toll-like receptor (TLR)2 and TLR4 on CD14dimCD16+ monocytes in response to sepsis-related antigens.
Skinner NA, MacIsaac CM, Hamilton JA, Visvanathan K.
Clin Exp Immunol. 2005 Aug;141(2):270-8.
PMID: 15996191 [PubMed – indexed for MEDLINE]Free PMC ArticleFree text0.

Peripheral blood mononuclear cell expression of toll-like receptors and relation to cytokine levels in cirrhosis.

Riordan SM, Skinner N, Nagree A, McCallum H, McIver CJ, Kurtovic J, Hamilton JA, Bengmark S, Williams R, Visvanathan K.
Hepatology. 2003 May;37(5):1154-64.
PMID: 12717397 [PubMed – indexed for MEDLINE]