Australian HIV Observational Database (AHOD)

The Australian HIV Observational Database (AHOD) is an observational cohort study of HIV infected individuals attending specialised general practitioner sites, sexual health clinics and tertiary referral centres throughout Australia. This study has been ongoing since 1999, and currently has 27 sites contributing a total of 2921 enrolled patients with average 5 years of follow-up data.

The primary objectives of the Australian HIV Observational Database are to monitor patterns of antiretroviral treatment use, including the efficacy of different treatment regimens, related to demographic factors and markers of HIV disease stage; patterns of toxicities/adverse events associated with antiretroviral treatment use, as well as to monitor HIV related and non-HIV related causes of death.

The core data collected include patient demographics, HIV disease stage (CD4 t-cell counts, HIV viral load and AIDS defining illness), as well as antiretroviral treatment, and laboratory data (including total cholesterol, HDL, haemoglobin, ALT and AST). Data are contributed to AHOD in electronic form from computerised patient management systems on a six monthly basis in agreed standardised formats. Data are merged, collated and summarised on the behalf of contributing sites at the Kirby Institute, University of New South Wales.

Summary reports of trends in antiretroviral treatment use are published on a yearly basis, and widely circulated in Australia. Summary data are also contributed to the Australian Annual Surveillance Report. Peer-reviewed articles have also been published. Reports and publication abstracts can be downloaded from the links below.

The Australian HIV Observational Database is funded as part of the Asia Pacific HIV Observational Database, a program of The Foundation for AIDS Research, amfAR, and is supported in part by a grant from the U.S. National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID) (Grant No. U01-AI069907) and by unconditional grants from Merck Sharp & Dohme; Gilead; Bristol-Myers Squibb; Boehringer Ingelheim; Roche; Pfizer; GlaxoSmithKline; Janssen-Cilag. The National Centre in HIV Epidemiology and Clinical Research is funded by The Australian Government Department of Health and Ageing, and is affiliated with the Faculty of Medicine, The University of New South Wales

Recent Publications

Temporal Trends of Time to Antiretroviral Treatment Initiation, Interruption and Modification: examination of patients diagnosed with advanced HIV in Australia.

Wright ST, Law MG, Cooper DA, Keen P, McDonald A, Middleton M, Woolley I, Kelly M, Petoumenos K, Australian HIV Observational Database.
Int J AIDS Soc 2015 [In Press]

Reducing viral load measurements to once a year in patients on stable, virologically suppressive cART regimen: findings from the Australian HIV Observational Database.
Mahshid R, Kariminia A, Wright S, Mills G, Woolley I, Smith D, Templeton JD, Law MG, Petoumenos K; Australian HIV Observational Database.
J AIDS Clin Res 2015 [In Press]
Rafiee M, Kariminia A, Wright S, Mills G, Woolley I, Smith D, Templeton DJ, Law MG, Petoumenos K.
J AIDS Clin Res 2014. 5:380. http://dx.doi.org/10.4172/2155-6113.1000383
Recent trends in response to combination antiretroviral therapy in Australia.
McManus H, Hoy JF, Woolley I, Boyd MA, Kelly MD, Mulhall B, Roth NJ, Petoumenos K, Law MG; the Australian HIV Observational Database.
Antivir Ther. 2014 Apr 4. doi: 10.3851/IMP2774. [Epub ahead of print]
PMID: 24704818 [PubMed – as supplied by publisher]

The significance of HIV ‘blips’ in resource-limited settings: is it the same? Analysis of the Treat Asia HIV Observational Database (TAHOD) and the Australian HIV Observational Database (AHOD).
Kanapathipillai R, McManus H, Kamarulzaman A, Lim PL, Templeton DJ, Law M, Woolley I.
PLoS One. 2014 Feb 7;9(2):e86122. doi: 10.1371/journal.pone.0086122. eCollection 2014.
PMID: 24516527 [PubMed – in process]

Determinants of Viraemia Copy-Years in People with HIV/AIDS Following Initiation of Antiretroviral Therapy.
Wright ST, Hoy J, Mulhall B, O’Connor CC, Petoumenos K, Read T, Smith D, Woolley I, Boyd MA; on behalf of the Australian HIV Observational Database.
J Acquir Immune Defic Syndr. 2014 Jan 23. [Epub ahead of print]
PMID: 24463783 [PubMed – as supplied by publisher]

The significance of low-level viremia in diverse settings: Analysis of the Treat Asia HIV Observational Database (TAHOD) and the Australian HIV Observational Database (AHOD).
Kanapathipillai R, McManus H, Giles ML, Ng OT, Cuoung DD, Nguyen K, Read T, Woolley I,
HIV Med. 2014 Jan 26. doi: 10.1111/hiv.12124. [Epub ahead of print]
PMID: 24460817 [PubMed – as supplied by publisher]

Loss to follow-up in the Australian HIV Observational Database.
McManus H, Petoumenos K, Brown K, Baker D, Russell D, Read T, Smith D, Wray L, Giles M, Hoy J, Carr A, Law M; the Australian HIV Observational Database.
Antivir Ther. 2014 Nov 7. doi: 10.3851/IMP2916. [Epub ahead of print]
PMID: 25377928 [PubMed – as supplied by publisher]
Incident hepatitis B infection subsequent to the diagnosis of HIV infection in a Melbourne cohort: missed opportunities for prevention.
Body A, Hoy JF, Cheng AC, Giles ML.
Sex Health. 2014 Mar;11(1):5-10. doi: 10.1071/SH13019.
PMID: 24157226 [PubMed – in process]
The significance of low-level viremia in diverse settings: Analysis of the Treat Asia HIV Observational Database (TAHOD) and the Australian HIV Observational Database (AHOD).
Kanapathipillai R, McManus H, Giles ML, Ng OT, Cuoung DD, Nguyen K, Read T, Woolley I,
HIV Med. 2014 Aug;15(7):406-16. doi: 10.1111/hiv.12124. Epub 2014 Jan 26.
PMID: 24460817 [PubMed – in process]
Antiretroviral Treatment Interruption and Loss to Follow-up in Two HIV cohorts in Australia and Asia: Implications for ‘Test and Treat’ Prevention Strategy.
Guy R, Wand H, McManus H, Vonthanak S, Woolley I, Honda M, Read T, Sirisanthana T, Zhou J, Carr A. on behalf of AHOD and TAHOD.
AIDS Patient Care STDS. 2013 Dec;27(12):681-91. doi: 10.1089/apc.2012.0439.
PMID:24320013 [PubMed – in process]

Cancer, immunodeficiency and antiretroviral treatment: results from the Australian HIV Observational Database (AHOD).
Petoumenos K, van Leuwen M , Vajdic C, Woolley I, Chuah J, Templeton DJ, Grulich A, Law M.
HIV Med. 2013 Feb;14(2):77-84. doi: 10.1111/j.1468-1293.2012.01038.x. Epub 2012 Aug 30.
PMID: 22934689 [PubMed – as supplied by publisher]

Long-term survival in HIV positive patients with up to 15 Years of antiretroviral therapy.
McManus H, O’Connor CC, Boyd M, Broom J, Russell D, Watson K, Roth N, Read PJ, Petoumenos K, Law MG; Australian HIV Observational Database.
PLoS One. 2012;7(11):e48839. doi: 10.1371/journal.pone.0048839. Epub 2012 Nov 7.
PMID: 23144991 [PubMed – in process] Free PMC Article

Differences in lipid measurements by antiretroviral regimen exposure in cohorts from Asia and australia.
Achhra AC, Amin J, Hoy J, Tanuma J, Sirisanthana T, Nolan D, Merati T, Giles M.
AIDS Res Treat. 2012;2012:246280. Epub 2012 May 14.
PMID: 22675613 [PubMed] Free PMC Article

Triple class experience after initiation of combination antiretroviral treatment in Australia: survival and projections.
Pour SM, Woolley I, Canavan P, Chuah J, Russell DB, Law M, Petoumenos, K.
Sex Health. 2011:8(3):295-303.

CD4 Cell Responses to Combination Antiretroviral Therapy in Patients Starting Therapy at High CD4 Cell Counts.
Wright ST, Carr A, Woolley I, Giles M, Hoy J, Cooper DA, Lawma MG; on behalf of the Australian HIV Observational Database..
J Acquir Immune Defic Syndr. 2011 Sep 1;58(1):72-9.
PMID: 21654498 [PubMed – as supplied by publisher]

Clinical predictors of immune reconstitution following combination antiretroviral therapy in patients from the Australian HIV Observational Database.
Rajasuriar R, Gouillou M, Spelman T, Read T, Hoy J, Law M, Cameron PU, Petoumenos K, Lewin SR.
PLoS One. 2011;6(6):e20713. doi: 10.1371/journal.pone.0020713. Epub 2011 Jun 2.
PMID: 21674057 [PubMed – indexed for MEDLINE] Free PMC Article

Predictors and outcomes of HIV-infected antiretroviral-naive patients with discordant responses to combination antiretroviral treatment in Asian and Australian populations: results from APHOD.
Choi JY, Zhou J, Giles M, Broom J, Templeton DJ, Law MG, Chaiwarith R, Tanuma J; Asia-Pacific HIV Observational Database.
J Acquir Immune Defic Syndr. 2011 May 1;57(1):e13-5. No abstract available.
PMID: 21786460 [PubMed – in process]

CD4 Cell Responses to Combination Antiretroviral Therapy in Patients Starting Therapy at High CD4 Cell Counts.
Wright ST, Carr A, Woolley I, Giles M, Hoy J, Cooper DA, Lawma MG; on behalf of the Australian HIV Observational Database..
J Acquir Immune Defic Syndr. 2011 Jun 7. [Epub ahead of print]
PMID: 21654498 [PubMed – as supplied by publisher]

The Clinical Significance of CD4 Counts in Asian and Caucasian HIV-Infected Populations: Results from TAHOD and AHOD.
Achhra AC, Zhou J, Choi JY, Hoy J, Zhang F, Templeton DJ, Merati T, Woolley I, Petoumenos K, Amin J.
J Int Assoc Physicians AIDS Care (Chic). 2011 May-Jun;10(3):160-70. Epub 2011 Apr 20.
PMID: 21508296 [PubMed – as supplied by publisher]

Trends in detectable viral load by calendar year in the Australian HIV Observational Database.
Law MG, Woolley I, Templeton DJ, Roth N, Chuah J, Mulhall B, Canavan P, McManus H, Cooper DA, Petoumenos K, Database TA.
J Int AIDS Soc. 2011 Feb 23;14(1):10.
PMID: 21345234 [PubMed – – indexed for MEDLINE] Free Article

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