MBBS (Hons) (Monash) FRACP PhD (Monash)

Director, Infections in Pregnancy service, Monash Infectious Diseases
Deputy Director, Monash HIV, Monash Infectious Diseases

Infectious DIseases Physician, Monash Immunisation
Adjuct Clinical Associate Professor, Department of Obstetrics and Gynaecology, School of Clinical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University

Also
Infectious Diseases Physician, Alfred Hospital
Infectious Diseases Physician, Royal Women’s Hospital
Infectious Diseases Physician, Victorian Infectious Diseases Service, Royal Melbourne Hospital

Professional Roles

2016-          Australian Technical Advisory Group on Immunisation (ATAGI)                       2015-          Victorian Immunisation Advisory Committee                                                         2013           InterAcademy Medical Panel Young Physician Leaders (YPL) programme, World Health Summit
2009-2012  NHMRC Australian based Clinical Research Fellowship
2009-2012  Antiretroviral Guidelines Panel, Australasian Society for HIV Medicine (ASHM)
2011           Organising committee, Australasian Society for HIV Medicine (ASHM) Annual Meeting
2009-2011   National Centre in HIV Epidemiology & Clinical Research Viral Hepatitis Working Group
2009            HIV National strategy expert writing reference group 2009
2008-2012  Australasian Society for HIV Medicine (ASHM) Board Member
2000-2002  Infectious Diseases consultant to the National Perinatal Statistics Unit

Awards
2008           Australian Society of Infectious Diseases (ASID) Council Scholarship
2005           Faculty Excellence Award Monash University
2005           Australian Herpes Management Forum Travel Grant Scholarship Award
2005           Clinical Medicine Presentation Award ASHM Annual Meeting
2005           ASHM Undergraduate & Junior Research Award
2004           GlaxoSmithKline Travel Award Most Outstanding Advanced Trainee Research Project
2003           ASID Annual Scientific Meeting Advanced Trainee Research Presentation Award

Books

Management of Perinatal Infections.
Palasanthiran P, Starr M, Jones C, Giles M. (eds)
Australasian Society for Infectious Diseases 2014.

Book Chapters

Giles ML, Workman C, Rodgers C.
Clinical manifestations of HIV infection
HIV Management in Australasia. A Guide for Clinical Care
Australasian Society for HIV Medicine, 2017

Managing hepatitis B virus infection in pregnancy and children.
Levy MT, Giles M, Hardikar W.
in Allard N, Matthews G, Robotin M (eds).
Australasian Society for HIV Medicine, 2014.
Management of the HIV-infected woman.
Kanapathipillai R. Giles ML.
In: Curtis M, Linares ST, Antoniewicz L. (eds).
Glass’ Office Gynecology (7th ed.)
Lippincott Williams & Wilkins, 2014.
Australasian Society for HIV Medicine, 2011.

Lamivudine.
Giles ML, Audsley J, Lewin SR.
In: Grayson ML, Crowe SM, McCarthy JS, Mills J, Mouton JW, Norrby SR, Paterson DL, Pfaller MA. (eds).
Kucers’ The Use of Antibiotics (6th ed.)

American Society for Microbiology & Hodder Arnold, 2010.

Clinical Manifestations and the Natural History of HIV.
Giles M, Workman C.
In: Hoy J. Lewin SR. Post JJ. Street A. (eds).
HIV Management in Australasia: A Guide for Clinical Care

Australasian Society for HIV Medicine, 2009.
HPV Vaccines.
Giles M. Garland SM.
In Campo MS (ed).
Caister Academic Press, 2006.

Journal articles

Concomitant medication polypharmacy, interactions and imperfect adherence are common in Australian adults on suppressive ART.
Siefried KJ, Mao L, Cysique LA, Rule J, Giles ML, Smith DE, Mcmahon J, Read TR, Ooi C, Tee BK, Bloch M, de Wit J, Carr A; PAART study investigators.
AIDS. 2017 Nov 10. doi: 10.1097/QAD.0000000000001685.

SOMANZ guidelines for the investigation and management sepsis in pregnancy.
Bowyer L, Robinson HL, Barrett H, Crozier TM, Giles M, Idel I, Lowe S, Lust K, Marnoch CA, Morton MR, Said J, Wong M, Makris A.
Aust N Z J Obstet Gynaecol. 2017 Oct;57(5):540-551. doi: 10.1111/ajo.12646. Epub 2017 Jul 3.
PMID: 28670748

Prevalence of self-reported comorbidities in HIV positive and HIV negative men who have sex with men over 55 years-The Australian Positive & Peers Longevity Evaluation Study (APPLES).
Petoumenos K, Huang R, Hoy J, Bloch M, Templeton DJ, Baker D, Giles M, Law MG, Cooper DA.
PLoS One. 2017 Sep 8;12(9):e0184583. doi: 10.1371/journal.pone.0184583. eCollection 2017.
PMID: 28886173

Vaccine decision-making begins in pregnancy: Correlation between vaccine concerns, intentions and maternal vaccination with subsequent childhood vaccine uptake.
Danchin MH, Costa-Pinto J, Atwell K, Willaby H, Wiley K, Hoq M, Leask J, Perrett KP, O’Keefe J, Giles ML, Marshall H.
Vaccine. 2017 Aug 12. pii: S0264-410X(17)31069-1. doi: 10.1016/j.vaccine.2017.08.003. [Epub ahead of print]
PMID: 28811050

Persistence of Activated and Adaptive-Like NK Cells in HIV+ Individuals despite 2 Years of Suppressive Combination Antiretroviral Therapy.
Hearps AC, Agius PA, Zhou J, Brunt S, Chachage M, Angelovich TA, Cameron PU, Giles M, Price P, Elliott J, Jaworowski A.
Front Immunol. 2017 Jun 30;8:731. doi: 10.3389/fimmu.2017.00731. eCollection 2017.
PMID: 28713370

Protecting newborns from pertussis: The role of partner vaccination in the era of maternal immunization.
Krishnaswamy S, Wallace EM, Cheng AC, Buttery J, Giles ML.
Eur J Obstet Gynecol Reprod Biol. 2017 Jul 25;216:159-163. doi: 10.1016/j.ejogrb.2017.07.031. [Epub ahead of print]
PMID: 28772257

Pregnant women’s attitudes toward antenatal pertussis vaccination.
Naidu MA, Krishnaswamy S, Wallace EM, Giles ML.
Aust N Z J Obstet Gynaecol. 2017 Apr;57(2):235. doi: 10.1111/ajo.12615. No abstract available.
PMID: 28401561

Timing of Prenatal Tdap Immunization and Protection Against Pertussis.
Abu Raya B, Giles M.
Clin Infect Dis. 2017 Mar 15;64(6):821-822. doi: 10.1093/cid/cix027. No abstract available.
PMID: 28362952

Manipulating the baby biome: What are the issues?
Lee LY, Garland SM, Giles ML, Daley AJ.
Aust N Z J Obstet Gynaecol. 2017 Apr;57(2):232-234. doi: 10.1111/ajo.12599. Epub 2017 Mar 22.
PMID: 28326541

Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy.
Rawlinson WD, Boppana SB, Fowler KB, Kimberlin DW, Lazzarotto T, Alain S, Daly K, Doutré S, Gibson L, Giles ML, Greenlee J, Hamilton ST, Harrison GJ, Hui L, Jones CA, Palasanthiran P, Schleiss MR, Shand AW, van Zuylen WJ.
Lancet Infect Dis. 2017 Mar 10. pii: S1473-3099(17)30143-3. doi: 10.1016/S1473-3099(17)30143-3. [Epub ahead of print] Review.
PMID: 28291720

Sexual transmission of HIV and the law: an Australian medical consensus statement.
Boyd M, Cooper D, Crock EA, Crooks L, Giles ML, Grulich A, Lewin SR, Nolan D, Yarwood T.
Med J Aust. 2016 Nov 7;205(9):409-412.
PMID: 27809738

Antenatal pertussis vaccination: Are we implementing best evidence into practice?
Krishnaswamy S, Wallace E, Buttery J, Giles M.
Aust N Z J Obstet Gynaecol. 2016 Dec;56(6):552-555. doi: 10.1111/ajo.12554. Review.
PMID: 27704540

The optimal gestation for pertussis vaccination during pregnancy – A prospective cohort study.
Naidu MA, Muljadi R, Davies-Tuck ML, Wallace EM, Giles ML.
Am J Obstet Gynecol. 2016 Aug;215(2):237.e1-6. doi: 10.1016/j.ajog.2016.03.002.
PMID: 26968625

How do outcomes compare between women and men living with HIV in Australia? An observational study.
Giles ML, Zapata MC, Wright ST, Petoumenos K, Grotowski M, Broom J, Law MG, O’Connor CC.
Sex Health. 2016 Apr;13(2):155-61. doi: 10.1071/SH15124.
PMID:26827052

Managing HBV in pregnancy. Prevention, prophylaxis, treatment and follow-up: position paper produced by Australian, UK and New Zealand key opinion leaders.
Visvanathan K, Dusheiko G, Giles M, Wong ML, Phung N, Walker S, Le S, Lim SG, Gane E, Ngu M, Hardikar W, Cowie B, Bowden S, Strasser S, Levy M, Sasaduesz J.
Gut. 2016 Feb;65(2):340-50. doi: 10.1136/gutjnl-2015-310317. Epub 2015 Oct 15. Review.
PMID: 26475631

HIV in pregnant women and prevention of perinatal transmission.
Giles M.
Microbiol Aust 2016;36(4):182-184.

A history of infection with varicella is strongly predictive of the presence of varicella-zoster virus antibodies in a heterogenous Australian HIV cohort.
Gurry GA, Dendle C, Korman TM, Giles ML, Williams JH, Woolley IJ.
AIDS. 2015 Sep 24;29(15):2062-2064. No abstract available.
PMID: 26352884

Factors associated with discussion of sexual activity and contraception in women with HIV.
Stewart ZA, Shipley K, Spelman T, Giles ML.
J Fam Plann Reprod Health Care. 2015 Apr 21. pii: jfprhc-2014-100937. doi: 10.1136/jfprhc-2014-100937. [Epub ahead of print]
PMID: 25900524
Giles M, Visvanathan K, Lewin S, Bowden S, Locarnini S, Spelman T, Sasadeusz J.
Gut. 2014 Nov 27. pii: gutjnl-2014-308211. doi: 10.1136/gutjnl-2014-308211. [Epub ahead of print]PMID:25431458
[PubMed – as supplied by publisher]
What has the Young Physician Leaders Programme achieved?
Giles ML, Vincent FB, Volkenstein S, Shefin SM, Silva A, Fredrick F; Young Physician Leadership Group 2013.
Lancet. 2014 Jul 5;384(9937):26-7. doi: 10.1016/S0140-6736(14)61108-9. No abstract available.
PMID: 24998810 [PubMed – indexed for MEDLINE]
Loss to follow-up in the Australian HIV Observational Database.
McManus H, Petoumenos K, Brown K, Baker D, Russell D, Read T, Smith D, Wray L, Giles M, Hoy J, Carr A, Law M; the Australian HIV Observational Database.
Antivir Ther. 2014 Nov 7. doi: 10.3851/IMP2916. [Epub ahead of print]
PMID: 25377928 [PubMed – as supplied by publisher]
Incident hepatitis B infection subsequent to the diagnosis of HIV infection in a Melbourne cohort: missed opportunities for prevention.
Body A, Hoy JF, Cheng AC, Giles ML.
Sex Health. 2014 Mar;11(1):5-10. doi: 10.1071/SH13019.
PMID: 24157226 [PubMed – in process]
The significance of low-level viremia in diverse settings: Analysis of the Treat Asia HIV Observational Database (TAHOD) and the Australian HIV Observational Database (AHOD).
Kanapathipillai R, McManus H, Giles ML, Ng OT, Cuoung DD, Nguyen K, Read T, Woolley I,
HIV Med. 2014 Aug;15(7):406-16. doi: 10.1111/hiv.12124. Epub 2014 Jan 26.
PMID: 24460817 [PubMed – in process]

Cytomegalovirus in pregnancy: to screen or not to screen.
Walker SP, Palma-Dias R, Wood EM, Shekleton P, Giles ML.
BMC Pregnancy Childbirth. 2013 Apr 18;13:96. doi: 10.1186/1471-2393-13-96. Review.
PMID: 23594714 [PubMed – indexed for MEDLINE]

Human immunodeficiency virus and menopause.
Kanapathipillai R, Hickey M, Giles M.
Menopause. 2013 Sep;20(9):983-90. doi: 10.1097/GME.0b013e318282aa57. Review.
PMID: 23531684 [PubMed – indexed for MEDLINE]

Prevention of mother-to-child transmission of hepatitis B virus (HBV) during pregnancy and the puerperium: Current standards of care.
Giles ML, Grace R, Tai A, Michalak K, Walker SP.
Aust N Z J Obstet Gynaecol. 2013 Jun;53(3):231-5. doi: 10.1111/ajo.12061. Epub 2013 Mar 4.
PMID: 23452292 [PubMed – indexed for MEDLINE]

HIV and pregnancy – how to manage conflicting recommendations from evidence based guidelines.
Giles ML.
AIDS. 2013 Mar 27;27(6):857-62. doi: 10.1097/QAD.0b013e32835ce308.
PMID: 23196940 [PubMed – indexed for MEDLINE]

A qualitative study of HIV serodiscordant patients accessing assisted reproductive treatment.
Peak SA, Nowoweiski SJ, Giles ML.
J Reprod Infant Psych 2012;30(4):413-422.
DOI:10.1080/02646838.2012.733362

Differences in lipid measurements by antiretroviral regimen exposure in cohorts from Asia and australia.
Achhra AC, Amin J, Hoy J, Tanuma J, Sirisanthana T, Nolan D, Merati T, Giles M.
AIDS Res Treat. 2012;2012:246280. Epub 2012 May 14.
PMID: 22675613 [PubMed] Free PMC Article

Influenza vaccination uptake amongst pregnant women and maternal care providers is suboptimal.
Lu AB, Halim AA, Dendle C, Kotsanas D, Giles ML, Wallace EM, Buttery JP, Stuart RL.
Vaccine. 2012 Jun 8;30(27):4055-9. doi: 10.1016/j.vaccine.2012.04.012. Epub 2012 Apr 19.
PMID:22521842 [PubMed – indexed for MEDLINE]

Chronic Hepatitis B Infection and Pregnancy.
Giles ML, Visvanathan K, Lewin SR, Sasadeusz J.
Obstet Gynecol Surv. 2012 Jan;67(1):37-44.
PMID: 22278077 [PubMed – as supplied by publisher]

Outcomes from the first assisted reproduction program for HIV-serodiscordant couples in Australia.
Giles ML, Barak S, Baker G, Perna S, Tabrizi S, Greengrass V, Bourne H, Clarke GN, Peak SA, Hoy JF, Foster P, Knight RL, On Behalf Of The CVI Study Group.
Med J Aust. 2011 Nov 21;195(10):599-601.
PMID: 22107010 [PubMed – in process]

Antiviral therapy for hepatitis B infection during pregnancy and breastfeeding.
Giles M, Visvanathan K, Sasadeusz J.
Antivir Ther. 2011;16(5):621-8.
PMID: 21817183 [PubMed – in process]

Predictors and outcomes of HIV-infected antiretroviral-naive patients with discordant responses to combination antiretroviral treatment in Asian and Australian populations: results from APHOD.
Choi JY, Zhou J, Giles M, Broom J, Templeton DJ, Law MG, Chaiwarith R, Tanuma J; Asia-Pacific HIV Observational Database.
J Acquir Immune Defic Syndr. 2011 May 1;57(1):e13-5. No abstract available.
PMID: 21786460 [PubMed – in process]

CD4 Cell Responses to Combination Antiretroviral Therapy in Patients Starting Therapy at High CD4 Cell Counts.
Wright ST, Carr A, Woolley I, Giles M, Hoy J, Cooper DA, Lawma MG; on behalf of the Australian HIV Observational Database..
J Acquir Immune Defic Syndr. 2011 Jun 7. [Epub ahead of print]
PMID: 21654498 [PubMed – as supplied by publisher]

Antenatal interventions for preventing the transmission of cytomegalovirus (CMV) from the mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant.
McCarthy FP, Giles ML, Rowlands S, Purcell KJ, Jones CA.
Cochrane Database Syst Rev. 2011 Mar 16;3:CD008371.
PMID: 21412919 [PubMed – in process]

2009 H1N1 influenza A and pregnancy outcomes in Victoria, Australia.
Hewagama S, Walker SP, Stuart RL, Gordon C, Johnson PD, Friedman ND, O’Reilly M, Cheng AC, Giles ML.
Clin Infect Dis. 2010 Mar 1;50(5):686-90.
PMID: 20100064 [PubMed – indexed for MEDLINE]

The “work” of women when considering and using interventions to reduce mother-to-child transmission (MTCT) of HIV.
Giles ML, Hellard ME, Lewin SR, O’Brien ML.
AIDS Care. 2009 Oct;21(10):1230-7.
PMID: 20024698 [PubMed – indexed for MEDLINE]

Perinatal exposure to HIV among children born in Australia, 1982-2006.
McDonald AM, Zurynski YA, Wand HC, Giles ML, Elliott EJ, Ziegler JB, Kaldor JM.
Med J Aust. 2009 Apr 20;190(8):416-20.
PMID: 19374612 [PubMed – indexed for MEDLINE]

Antenatal screening practice for infectious diseases by general practitioners in Australia.
Giles ML, Pedrana A, Jones C, Garland S, Hellard M, Lewin SR.
Aust N Z J Obstet Gynaecol. 2009 Feb;49(1):39-44.
PMID: 19281578 [PubMed – indexed for MEDLINE]

HIV and pregnancy: screening and management update.
Giles M.
Curr Opin Obstet Gynecol. 2009 Apr;21(2):131-5. Review.
PMID: 19276805 [PubMed – indexed for MEDLINE]

Primary and secondary cytomegalovirus infection in pregnancy.

McCarthy FP, Jones C, Rowlnads S, Giles M.
The Obstetrician & Gynaecologist. 2009;11:2:96-100.

Unrecognised vitamin D deficiency: low concentrations in African migrants with HIV in Australia.
Woolley IJ, Giles ML, Howard JE, Korman TM.
Sex Health. 2008 Dec;5(4):375-6. No abstract available.
PMID: 19189504 [PubMed – indexed for MEDLINE]

HIV transmission: the ongoing importance of antenatal screening.
Upjohn LM, Korman TM, Giles ML.
N Z Med J. 2008 Sep 5;121(1281):94-5. No abstract available.
PMID: 18797491 [PubMed – indexed for MEDLINE]

Variable uptake of recommended interventions to reduce mother-to-child transmission of HIV in Australia, 1982-2005.
Giles ML, McDonald AM, Elliott EJ, Ziegler JB, Hellard ME, Lewin SR, Kaldor JM.
Med J Aust. 2008 Aug 4;189(3):151-4.
PMID: 18673102 [PubMed – indexed for MEDLINE]Free Article

What are the barriers to offering HIV testing in an antenatal setting? A national study of obstetricians.
Giles ML, Garland SM, Lewin SR, Hellard ME.
AIDS. 2007 Jul 31;21(12):1601-6.
PMID: 17630555 [PubMed – indexed for MEDLINE]

A comparison of three typing methods for Serratia marcescens during an outbreak across four neonatal intensive care units.
Giles M, Tabrizi S, Grabsch E, Friedman ND, Gillespie E, Kotsanas D, Li H, Korman TM, Daley A.
Aust Infect Control. 2007; 12(1) 20 – 24.

Tuberculosis in pregnancy – case studies and a review of Australia’s screening process.

McCarthy FP, Rowlands S, Giles M.
Aust N Z J Obstet Gynaecol. 2006 Oct;46(5):451-5.
PMID: 16953862 [PubMed – indexed for MEDLINE]

The evidence for a change in antenatal HIV screening policy in Australia.
Giles ML, Hellard ME, Lewin SR, Mijch AM.
Med J Aust. 2006 Aug 21;185(4):217-20.
PMID: 16922668 [PubMed – indexed for MEDLINE]Free Article

A study of women’s knowledge regarding human papillomavirus infection, cervical cancer and human papillomavirus vaccines.
Giles M, Garland S.
Aust N Z J Obstet Gynaecol. 2006 Aug;46(4):311-5.
PMID: 16866792 [PubMed – indexed for MEDLINE]

Human papillomavirus infection: an old disease, a new vaccine.
Giles M, Garland S.
Aust N Z J Obstet Gynaecol. 2006 Jun;46(3):180-5. Review.
PMID: 16704468 [PubMed – indexed for MEDLINE]

Invasive Haemophilus parainfluenzae maternal-infant infections: an Australasian perspective and case report.
Rele M, Giles M, Daley AJ.
Aust N Z J Obstet Gynaecol. 2006 Jun;46(3):258-60. Review.
PMID: 16704486 [PubMed – indexed for MEDLINE]

What is the best screening method to detect Serratia marcescens colonization during an outbreak in a neonatal intensive care nursery?
Giles M, Harwood HM, Gosling DA, Hennessy D, Pearce CT, Daley AJ.
J Hosp Infect. 2006 Mar;62(3):349-52. Epub 2005 Dec 5.
PMID: 16337029 [PubMed – indexed for MEDLINE]

Impact of an education campaign on management in pregnancy of women infected with a blood-borne virus.
Giles ML, Garland SM, Grover SR, Lewin SM, Hellard ME.
Med J Aust. 2006 Apr 17;184(8):389-92.
PMID: 16618237 [PubMed – indexed for MEDLINE]Free Article

Assisted reproduction for HIV-infected couples.
Giles M, Mijch A, Garland S.
Sex Health. 2005;2(4):223-7. Review.
PMID: 16402669 [PubMed – indexed for MEDLINE]

Breast milk pasteurisation in developed countries to reduce HIV transmission. Do the benefits outweigh the risks?
Giles M, Mijch A.
Infect Dis Obstet Gynecol. 2005 Dec;13(4):237-40.
PMID: 16338785 [PubMed – indexed for MEDLINE]Free PMC ArticleFree text

Management of preterm prelabour rupture of membranes: an audit. How do the results compare with clinical practice guidelines?
Giles M, Garland S, Oats JJ.
Aust N Z J Obstet Gynaecol. 2005 Jun;45(3):201-6.
PMID: 15904444 [PubMed – indexed for MEDLINE]

HIV and pregnancy in Australia.

Giles ML, Mijch AM, Garland SM, Grover SR, Hellard ME.
Aust N Z J Obstet Gynaecol. 2004 Jun;44(3):197-204. Review.
PMID: 15191442 [PubMed – indexed for MEDLINE]

An audit of obstetricians’ management of women potentially infected with blood-borne viruses.
Giles ML, Sasadeusz JJ, Garland SM, Grover SR, Hellard ME.
Med J Aust. 2004 Apr 5;180(7):328-32.
PMID: 15059052 [PubMed – indexed for MEDLINE]Free Article

Hepatitis C and pregnancy: an update.
Giles M, Hellard M, Sasadeusz J.
Aust N Z J Obstet Gynaecol. 2003 Aug;43(4):290-3. Review.
PMID: 14714713 [PubMed – indexed for MEDLINE]

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